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Fig. 1 | Cancer Cell International

Fig. 1

From: Characterization of a novel glucocorticoid-resistant human B-cell acute lymphoblastic leukemia cell line, with AMPK, mTOR and fatty acid synthesis pathway inhibition

Fig. 1

Establishment and resistance characteristics of NALM-6/HDR and its monoclone cell lines. a Flow chart for constructing the GC-resistant NALM-6/HDR cell lines. b IC50 and RI of the subclones of NALM-6/HDR cells to Dex. Cells were cultured with increasing concentrations of Dex for 48 h. Cell viability was evaluated by MTT assays. The IC50 values were calculated by linear interpolation. Experiments were performed in triplicate. c–g IC50 of NALM-6, NALM-6/HDR, NALM-6/HDR-C5, and NALM-6/H cells to L-Asp, DNR, VCR, Ara-c, and MTX. Cells were cultured with increasing concentrations of different drugs for 48 h. Cell viability was evaluated by MTT assays. The IC50 values were calculated by linear interpolation. Experiments were performed in triplicate. h RI of NALM-6/HDR, NALM-6/HDR-C5, and NALM-6/H cells to L-Asp, DNR, VCR, Ara-c, and MTX

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Cancer Cell International

ISSN: 1475-2867

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