Fig. 2
From: PESV represses non-small cell lung cancer cell malignancy through circ_0016760 under hypoxia
Circ_0016760 knockdown partly abolished the impacts of hypoxia treatment on NSCLC cell malignancy. A Circ_0016760 expression was determined by qRT-PCR in A549 and H1299 cells transfected with si-con, si-circ_0016760#1, si-circ_0016760#2 or si-circ_0016760#3. B The influence of circ_0016760 knockdown on circ_0016760 expression under hypoxia was detected by qRT-PCR in A549 and H1299 cells. C, D The impacts of circ_0016760 repression on the migration and invasion of A549 and H1299 cells after hypoxia treatment were demonstrated by transwell assay. E, F Cell colony formation and MTT assays were employed to investigate the effect of circ_0016760 knockdown on the proliferation of A549 and H1299 cells under hypoxia. (G) The effect of circ_0016760 silencing on PCNA expression under hypoxia was determined by western blot. H Tube formation assay was performed to reveal the impact of circ_0016760 knockdown on tube formation under hypoxia. *P < 0.05