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Table 1 Eribulin 2D and 3D GI50 values (nM). Concentration is displayed as ± standard deviation. 3D/2D ratio is also shown

From: Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?

Cell line Sarcoma subtype Eribulin GI50 2D Eribulin GI50 3D GI50 3D/ GI50 2D
HT1080 FS 5.07 ± 2.37 4.67 ± 1.75 0.92
SK-UT-1 LMS 0.17 ± 0.04 0.39 ± 0.13 2.29
SW872 PLPS 2.18 ± 0.18 3.54 ± 2.49 1.62
LIPODL221 MLPS 1.03 ± 0.22  > 100 NE
93T449 WDLPS 1.24 ± 0.17 47.93 ± 16.92 38.65
LPS224 DDLPS 11.75 ± 0.86  > 100 NE
LPS246 DDLPS 1.25 ± 0.12  > 100 NE
  1. FS Fibrosarcoma, LMS Leiomyosarcoma, PLPS Pleomorphic liposarcoma, MLPS Mixoid liposarcoma, WDLPS Well-differentiated liposarcoma, DDLPS Dedifferentiated liposarcoma, NE Not evaluable