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Table 1 Eribulin 2D and 3D GI50 values (nM). Concentration is displayed as ± standard deviation. 3D/2D ratio is also shown

From: Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?

Cell line

Sarcoma subtype

Eribulin GI50 2D

Eribulin GI50 3D

GI50 3D/ GI50 2D

HT1080

FS

5.07 ± 2.37

4.67 ± 1.75

0.92

SK-UT-1

LMS

0.17 ± 0.04

0.39 ± 0.13

2.29

SW872

PLPS

2.18 ± 0.18

3.54 ± 2.49

1.62

LIPODL221

MLPS

1.03 ± 0.22

 > 100

NE

93T449

WDLPS

1.24 ± 0.17

47.93 ± 16.92

38.65

LPS224

DDLPS

11.75 ± 0.86

 > 100

NE

LPS246

DDLPS

1.25 ± 0.12

 > 100

NE

  1. FS Fibrosarcoma, LMS Leiomyosarcoma, PLPS Pleomorphic liposarcoma, MLPS Mixoid liposarcoma, WDLPS Well-differentiated liposarcoma, DDLPS Dedifferentiated liposarcoma, NE Not evaluable
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Cancer Cell International

ISSN: 1475-2867

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