Fig. 5

Overexpression of RPS15A alleviates the promotion effects of TMED3 knockdown in TNBC cells. A According to TARGET-OS database, the correlation between RPS15A and TMED3 expression in osteosarcoma was analyzed by Spearman Correlation Coefficient. Cell models were subjected to the detection of proliferation (B), colony (C) and apoptosis (D). The cell migration ability was accessed by wound-healing assay (E) and Transwell assay (F). BALB/c nude mice were randomly divided into NC (OE + KD), TMED3 + NC (KD), shRPS15A + NC (OE), TMED3 + shRPS15A; n = 6 per group) and detected the growth and expression of KI67 in mice. The representative images were selected from at least 3 independent experiments. Data was shown as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001