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Fig. 3 | Cancer Cell International

Fig. 3

From: The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis

Fig. 3

Methylation levels at the ESR1 CpG island between patients’ subgroups. A Premenopausal and postmenopausal subgroups. Methylation levels were significantly higher in postmenopausal than in premenopausal samples (*p < 0.05). B Methylation level for pre and postmenopausal women. Controls and BC subgroups were analyzed separately by methylation state, showing that methylation levels of controls and ERα− samples belonging to the postmenopausal subgroup (black), were significantly higher than in premenopausal (white) (*p < 0.05). C Tumor phenotype subgroups. Methylation levels at ESR1 were higher in HER2+ and triple-negative phenotypes and lowered in luminal A and luminal/HER2+ phenotypes. HER2+ samples were significantly different from luminal A, luminal/HER2+, and mixed phenotypes (*p < 0.05), while triple-negative phenotype was statistically different than luminal A and luminal/HER2+ phenotypes (*p < 0.05)

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Cancer Cell International

ISSN: 1475-2867

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