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Table 1 Clinicopathological characteristics of the studied population

From: The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis

 

Case

Control

P

n (%)

n (%)

Cancer family history

 Yes

24 (63.16)

7 (40.0)

0.0410*

 No

14 (36.84)

13 (60.0)

 

n (%), age+

n (%), age+

 

Menopause

 Premenopause

12 (31.6) 41.33 ± 5.97

15 (75.0) 34.80 ± 12.42

0.0016*

 Postmenopause

26 (68.4) 57.58 ± 12.56

5 (25.0) 49.60 ± 20.21

Cancer stage grouping

 I

1 (2.6)

NA

 

 II

18 (47.4)

NA

 

 III

15 (39.5)

NA

 

 IV

4 (10.5)

NA

 

Phenotype

 Luminal/HER2+

11 (28.9)

NA

 

 HER2+

11 (28.9)

NA

 

 Luminal A

4 (10.5)

NA

 

 Mixed phenotypea

7 (18.4)

NA

 

 Triple-negative

5 (13.2)

NA

 
 

Case, n (%)

Control, n (%)

P

Immunohistochemical profileb

 Estrogen receptor (ER)

Positive

Negative

 

 Triple-negative

19 (50.0)

19 (50.0)

NA

 Progesterone receptor

18 (47.4)

20 (52.6)

NA

 HER2+

26 (68.4)

12 (31.6)

NA

  1. NA not applicable, n sample size
  2. P = statistically significant value was considered as P < 0.05 using Chi-square test
  3. aPopulation expressing both: and estrogen receptor or progesterone receptor
  4. bComparative analysis into case group only