Table 1 The regulatory mechanism of miRNAs on E-cadherin in thyroid cancer cells
From: E-cadherin on epithelial–mesenchymal transition in thyroid cancer
miRNAs | Status in TCs | Cell line origin | Regulation and control approach | Evidence of regulating E-cadherin in TCs | References |
|---|---|---|---|---|---|
miR-203 | L | TPC-1 | Up-regulation of AKT | Low expression of E-cadherin Induction of EMT T | [118] |
miR-597-3P | L | SW579 | Targeted up-regulation of RAB23 | Low expression of E-cadherin Induction of EMT | [119] |
miR-599 | L | TPC-1 | Targeted inhibition of Hey2 to inhibit Notch signaling pathway | High expression of Snail and Slug, low expression of E-cadherin Induction of EMT | [125] |
miR-20b | L | K1, TPC-1 | Up-regulating SOS1 and ERK2 to activate MAPK/ERK signaling pathway (up-regulation of p-MEK1/2, p-ERK1/2, t-ERK2) | Low expression of E-cadherin Induction of EMT | [128] |
miR-199a-5p | L | 8505C, SW1736 | Targeted up-regulation of Snail | Low expression of E-cadherin Induction of EMT | [127] |
miR-199a-5p | L | b-CPAP, SW579 | Targeted up-regulation of STON2 | Low expression of E-cadherin Induction of EMT | [129] |
miR-215 | L | K1, b-CPAP, TPC-1, IHH4 | Up-regulating ARFGEF1 to activate AKT/GSK-3β signaling pathway (up-regulation of p-AKT, p-GSK-3β) | High expression of Snail, low expression of E-cadherin Induction of EMT | [130] |
miR-451a | L | b-CPAP, KTC-1 | Targeted up-regulation of PSMB8 | Low expression of E-cadherin Induction of EMT | [131] |
miR-613 | L | K1, TPC-1, b-CPAP | Targeted up-regulation of TAGLN2 | Low expression of E-cadherin Induction of EMT | [132] |
miR-630 | L | SW1763, TPC-1 | Activation of JAK/STAT3 signal path (up-regulation of p-JAK、p-ATAT3) | Low expression of E-cadherin Induction of EMT | [133] |
miR-483-3p | H | 8580C, FRO | Targeted inhibition of PARDS | High expression of Snail, Slug, Zeb1 and Twist, low expression of E-cadherin Induction of EMT | [124] |
miR-31 | L | TPC-1, b-CPAP | Up-regulating Sox11 to activate ERK and AKT signaling pathway (up-regulation of p-ERK1/2, p-AKT) | Low expression of E-cadherin Induction of EMT | [126] |