Table 2 The regulatory mechanism of lncRNAs on E-cadherin in thyroid cancer cells
From: E-cadherin on epithelial–mesenchymal transition in thyroid cancer
LncRNAs | Status in TCs | Cell line origin | Regulation and control approach | Evidence of regulating E-cadherin in TCs | References |
|---|---|---|---|---|---|
UCA1 | H | TPC-1 | Down-regulation of miR-15a to activate Hippo and JNK signaling pathways (up-regulation of p/t-MST, p/tYAP, p/t-c-junĺ’Śp/t-JNK) | High expression of Snail and Zeb1, low expression of E-cadherin Induction of EMT | [146] |
TUG1 | H | FTC-133 | Down-regulation of miR-145 | High expression of Zeb1, low expression of E-cadherin Induction of EMT | [147] |
NORAD | H | K1, bCPAP, TPC1, NPA187 | Down-regulation of miR-202-5p | High expression of Zeb1, low expression of E-cadherin Induction of EMT | [136] |
LINC02471 | H | TPC-1, IHH4 | Down-regulation of miR-375 | High expression of Snail, low expression of E-cadherin Induction of EMT | [148] |
PAR5 | L | 8505C, FRO | Up-regulation of EZH2 | Low expression of E-cadherin Induction of EMT | [143] |
ZFAS1 | H | TPC-1 | Inhibition of miR-373-3p/MMP-3 axis | High expression of Snail and Slug, low expression of E-cadherin Induction of EMT | [154] |
LINC00637 | H | TPC-1, bCPAP | Down-regulation of Kruppel-like factor 2(KLF2) | Low expression of E-cadherin Induction of EMT | [149] |
LINC01816 | H | C643 | Sponge action on miR-34c-5p to upregulate CRABP2 | Low expression of E-cadherin Induction of EMT | [151] |
BANCR | H | bCPAP | Activation of Raf/MEK/ERK (up-regulation of p-c-Raf, p-ERK1/2, p-MEK1/2) | Low expression of E-cadherin Induction of EMT | [144] |
LINC00106 | L | bCPC, TPC-1 | Down-regulation of β-catenin | Low expression of E-cadherin Induction of EMT | [152] |
HOTAIR | H | TPC-1 | Activation of Wnt/β-catenin (down-regulation of WIFI, up-regulation of β-catenin) | Low expression of E-cadherin Induction of EMT | [19] |
LINC00313 | H | TPC-1, SW579 | The methylated proteins (DNMT1 and DNMT3b) promoted the methylation of ALX4 to activate AKT-mTOR signaling pathway (up-regulation of p-mTOR and p-AKT) | Low expression of E-cadherin Induction of EMT | [153] |
N384546 | H | KTC-1, bCPAP | Activation of miR-145-5p/AKT (down-regulation of miR-145-5p to activate Akt) | Low expression of E-cadherin Induction of EMT | [140] |
SLC26A4-AS1 | L | TPC-1 | Activation of MAPK signal pathway (up-regulation of p-JNK1/2 and ERK, down-regulation of TP53) | Low expression of E-cadherin Induction of EMT | [138] |