Fig. 8

CCND2 expression was modulated by the CRNDE/miR-545-5p axis. a The prediction of TargetScan and the detection of dual luciferase reporter assays demonstrated that CCND2 was a target of miR-545-5p. b CCND2 was expressed in a human normal nasopharyngeal epithelial cell line (NP69) and NPC cell lines (CNE-2Z, HNE-1, 5-8F). c Downregulating CRNDE or upregulating miR-545-5p can affect expression of CCND2 in NPC cells (CNE-2Z, HNE-1). d Western blot was used to detect the changes of CCND2 expression in NPC cells (CNE-2Z, HNE-1) when miR-545-5p was up-regulated or down-regulated. e Western blot was used to detect the expression of CCND2 when CRNDE was down-regulated and miR-545-5p was up-regulated or down-regulated. *p < 0.05; **p < 0.01