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Table 3 Univariate and multivariate Cox proportional hazards regression analysis for OS

From: HPV E6/E7 mRNA in situ hybridization in endocervical adenocarcinoma: implications for prognosis and diagnosis

Variables Univariate analysis Multivariate analysis
HR (95% CI) P value HR (95% CI) P value
Age (≤ 37 vs. > 37 years) 0.316 (0.154–0.649) 0.002 0.224 (0.095–0.530) 0.001
HPV DNA (negative vs. positive vs. na) 0.868 (0.500–1.509) 0.616   
HPV genotype (negative vs. positive vs. na) 1.004 (0.523–1.926) 0.992   
HPV RNAscope (≤ 3.3 vs. > 3.3) 0.337 (0.156–0.730) 0.006 0.288 (0.124–0.673) 0.004
Tumor size (≤ 4.5 vs. > 4.5 cm) 3.165 (1.414–7.083) 0.005 0.773 (0.223–2.674) 0.684
FIGO stage (I vs. II vs. III vs. IV) 2.821 (1.703–4.672)  < 0.001 1.120 (0.613–2.013) 0.705
Histological type (HPVA vs. NHPVA) 0.266 (0.108–0.657) 0.004 1.365 (0.334–5.589) 0.665
Differentiation (good vs. moderate vs. poor) 1.435 (0.768–2.684) 0.258   
LVI (none vs. focal vs. moderate vs. extensive) 2.056 (1.508–2.803)  < 0.001 1.770 (1.212–2.587) 0.003
Invasion level of uterine cervix (1/3 vs. 1/3–2/3 vs. 2/3) 3.147 (1.754–5.648)  < 0.001 1.532 (0.791–2.967) 0.206
Lymph nodes invasion (no vs. yes) 9.310(4.533–19.120)  < 0.001 2.838 (1.162–6.931) 0.022
Parametrium invasion (no vs. yes) 0.231 (0.094–0.568) 0.001 0.696 (0.217–2.234) 0.543
Surgical margin (no vs. yes) 0.263 (0.101–0.687) 0.006 1.621 (0.435–6.048) 0.472
Treatment (s vs. s + ct vs. s + rt vs. s + cr) 1.733 (1.298–2.313)  < 0.001 1.182 (0.851–1.641) 0.318
MMR status (dMMR vs. pMMR) 1.401 (0.426–4.610) 0.579   
P16 IHC (negative vs. positive) 0.478 (0.237–0.963) 0.039 1.203 (0.507–2.854) 0.675
Ki-67 IHC (≤ 12.5% vs. > 12.5%) 0.446 (0.220–0.906) 0.025 0.841 (0.348–2.035) 0.701
  1. HR hazard ratio, CI confidence interval, HPVA HPV-associated adenocarcinoma, NHPVA non HPV-associated adenocarcinoma, IHC immunohistochemistry, LVI lymph vascular invasion, dMMR delete mismatch repair, pMMR proficient mismatch repair, HPV genotype positive, HPV16, HPV18 and other types; s, surgery; s + ct, surgery + chemotherapy; s + rt, surgery + radiotherapy; s + cr, surgery + chemoradiation; na, not avaiable