Table 3 Univariate and multivariate Cox proportional hazards regression analysis for OS
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Age (≤ 37 vs. > 37 years) | 0.316 (0.154–0.649) | 0.002 | 0.224 (0.095–0.530) | 0.001 |
HPV DNA (negative vs. positive vs. na) | 0.868 (0.500–1.509) | 0.616 |  |  |
HPV genotype (negative vs. positive vs. na) | 1.004 (0.523–1.926) | 0.992 |  |  |
HPV RNAscope (≤ 3.3 vs. > 3.3) | 0.337 (0.156–0.730) | 0.006 | 0.288 (0.124–0.673) | 0.004 |
Tumor size (≤ 4.5 vs. > 4.5 cm) | 3.165 (1.414–7.083) | 0.005 | 0.773 (0.223–2.674) | 0.684 |
FIGO stage (I vs. II vs. III vs. IV) | 2.821 (1.703–4.672) |  < 0.001 | 1.120 (0.613–2.013) | 0.705 |
Histological type (HPVA vs. NHPVA) | 0.266 (0.108–0.657) | 0.004 | 1.365 (0.334–5.589) | 0.665 |
Differentiation (good vs. moderate vs. poor) | 1.435 (0.768–2.684) | 0.258 |  |  |
LVI (none vs. focal vs. moderate vs. extensive) | 2.056 (1.508–2.803) |  < 0.001 | 1.770 (1.212–2.587) | 0.003 |
Invasion level of uterine cervix (1/3 vs. 1/3–2/3 vs. 2/3) | 3.147 (1.754–5.648) |  < 0.001 | 1.532 (0.791–2.967) | 0.206 |
Lymph nodes invasion (no vs. yes) | 9.310(4.533–19.120) |  < 0.001 | 2.838 (1.162–6.931) | 0.022 |
Parametrium invasion (no vs. yes) | 0.231 (0.094–0.568) | 0.001 | 0.696 (0.217–2.234) | 0.543 |
Surgical margin (no vs. yes) | 0.263 (0.101–0.687) | 0.006 | 1.621 (0.435–6.048) | 0.472 |
Treatment (s vs. s + ct vs. s + rt vs. s + cr) | 1.733 (1.298–2.313) |  < 0.001 | 1.182 (0.851–1.641) | 0.318 |
MMR status (dMMR vs. pMMR) | 1.401 (0.426–4.610) | 0.579 |  |  |
P16 IHC (negative vs. positive) | 0.478 (0.237–0.963) | 0.039 | 1.203 (0.507–2.854) | 0.675 |
Ki-67 IHC (≤ 12.5% vs. > 12.5%) | 0.446 (0.220–0.906) | 0.025 | 0.841 (0.348–2.035) | 0.701 |