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Fig. 1 | Cancer Cell International

Fig. 1

From: The circular RNA circSLC7A11 functions as a mir-330-3p sponge to accelerate hepatocellular carcinoma progression by regulating cyclin-dependent kinase 1 expression

Fig. 1

Identification of circSLC7A11 as a circRNA associated with hepatocellular carcinoma (HCC) progression. a Volcano plot of circRNA abundance in three HCC tissues and their paired adjacent tissues. Horizontal dashed line corresponds to p = 0.01. Vertical dashed lines correspond to upregulation (fold change > 4) and downregulation (fold change < –4). b Venn diagram showing the overlapping of differentially expressed circRNAs identified through RNA sequencing (RNA-seq) (left) and liver-specific circRNAs identified in the circBase database (right). c Heatmap of 24 overlapping liver-specific differentially expressed circRNAs relative to paired adjacent tissues. Rows represent circRNAs; columns represent tissues. d, e Relative expression of circSLC7A11 in HCC tissues and paired adjacent tissues detected by quantitative reverse-transcription polymerase chain reaction (qRT-PCR) T, tumor (n = 93); N, non-tumor (n = 93) (p = 0.0053). f Relative expression of circSLC7A11 in HCC cell lines relative to the immortalized hepatocyte cell line WRL68. Data are mean ± standard deviation (SD) (ns = not significant; *p < 0.05; **p < 0.01; ***p < 0.001)

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