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Fig. 6 | Cancer Cell International

Fig. 6

From: CircTUBGCP3 facilitates the tumorigenesis of lung adenocarcinoma by sponging miR-885-3p

Fig. 6

miR-885-3p reversed circTUBGCP3-induced wnt10b signaling activation. A The luciferase activity of WT or Mut Wnt10B 3’UTR after the treatment with miR-885-3p inhibitor in NCI-H460 cells or its mimic in A549 cells. B TCGA validation of the upregulation of Wnt10B in 59 paired and 481 unpaired LAC tissue samples. C TCGA cohort indicated the negative correlation of miR-885-3p with Wnt10B in LAC tissues, and Kaplan Meier analysis of the association of high or low Wnt10B expression with overall survival in LAC patients. D Western blot analysis of the efficiencies of si-wnt10b in HCI-460 cells or wnt10B plasmids in A549 cells. E The effects of wnt10b knockdown or overexpression on cell colony formation. F Western blot analysis of the activity of Wnt10B/β-catenin signaling after the co-transfection with miR-885-3p inhibitor and si-circTUBGCP3 in NCI-H460 cells or miR-885-3p mimics and circTUBGCP3 in A549 cells. Data are the means ± SEM of three experiments. *P < 0.05, **P < 0.01

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