Fig. 2

The immune landscape in distinct cellular senescence-related molecular patterns in LUAD. A Single-sample gene set enrichment (ssGSEA) analysis identifying the relative infiltration level of immune cell populations in three cellular senescence clusters of LUAD samples in TCGA cohort. (B-C) Differences in regulatory T cell (B) and MDSC (C) proportion among distinct cellular senescence patterns in TCGA cohorts. D The relative distributions of leukocyte fraction, stromal fraction, SNV neoantigens, Indel neoantigens, and ITH score were compared among three cellular senescence clusters. E Heatmap depicting the mean values of mRNA expressions of immune-related genes among distinct clusters. F–G Comparisons of TCR Shannon, BCR Shannon (F), IPS and TIDE score (G) among three cellular senescence clusters. The statistical difference of three clusters were compared through the Kruskal–Wallis test. G Alluvial diagram showing the relations of cellular senescence clusters (upper) and TME subtype (lower) across LUAD patients. The statistical difference of three clusters were compared through the Kruskal–Wallis test. ns not significant; *P < 0.05; **P < 0.01; ***P < 0.001