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Fig. 6 | Cancer Cell International

Fig. 6

From: Identification and validation of cellular senescence patterns to predict clinical outcomes and immunotherapeutic responses in lung adenocarcinoma

Fig. 6

Response and survival predictive performance of CSS in immunotherapy. A The fraction of tumor-infiltrating immune cells between CSS-low and CSS-high groups in TCGA cohort by ssGSEA. B Comparison of checkpoints genes expressions (PD-L1, PD-1, and CTLA4) between CSS-low and CSS-high groups. CE Kaplan–Meier curves for four patient groups stratified by CCS and immune checkpoint genes (PD-L1 (C), PD-1 (D), CTLA4 (E)). FH IPS(F), TIDE score (G) and T cell Exclusion score (H) were compared between CSS-low and CSS-high subgroups in TCGA cohort. I The comparison of AUC of CSS, TIDE score, and IPS for OS in TCGA cohort. J Kaplan–Meier survival curves for patients with low and high CSS in anti-PD-L1 or anti-PD1-treated lung cohort. The statistical differences between two groups were compared through the Wilcoxon test. ns not significant; *P < 0.05; **P < 0.01; ***P < 0.001

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