Fig. 1

The diagram shows the schematic structure of the gene and protein of A-MYB, B-MYB and c-MYB. A The domain structures of A-MYB, B-MYB, and c-MYB. The MYB protein is diagrammed, with N-terminal on the left and C-terminal on the right. The labels at the bottom of the diagram indicate conserved domains. The MYB gene is located on chromosome 6q23.3 and encodes a transcription factor with an N-terminal DNA binding domain (DBD), a central transactivation domain (TAD), and a negative regulatory domain (NRD). Oncogenic activity requires the FAETL domain, the TPTPF domain conserved in the other MYB proteins, and the EVES domain that is involved in intra-molecular interactions and negative regulation. B MYB transcriptional elongation regulation model, and the effect of the interaction between ncRNAs and MYB on the occurrence and development of tumor cells