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Table 1 The role of miRNAs targeted by MYB in cancer development

From: Intricate crosstalk between MYB and noncoding RNAs in cancer

MYB-targeted miRNAs Expression Targeting Cellular processes Tumor types In vitro model In vivo model Refs.
miR-520-h Upregulated Smad7, MAGI1 Metastasis RCC, EOC RCC cell lines (786-O, A-498, OS-RC-2, ACHN, CAKI-1, SKRC39 and HK-2) BALB/C nude mice [48]
miR-130a Upregulated NDRG2 Cell proliferation, metastasis SACC SACC-83, SACCLM cells Female BALB/C-nu/nu nude mice [47]
miR-155 Upregulated PU.1 Cell proliferation, metastasis, cell cycle AML   PU.1/p53 double-mutant mice [51]
miR-17-92 Upregulated FRZB, p21, E2F1 Senescence Ph-positive leukemia BV173, SUP-B15 and K562 NOD/SCID gamma mice [131]
miR-143 Upregulated Ras Cell proliferation, apoptosis, DNA repair, metastasis. Nasopharyngeal carcinoma Human NPC cell lines, c666-1, 5-8F, CNE1 and CNE2   [42]
miR-1258 Downregulated SP-1, GRB2 Metastasis, cell cycle, senescence OSCC, NSCLC OSCC cell lines (SCC-9, SCC-15); Human NSCLC cell lines (A549, SPCA1, H1299, H358, PC9, 95D,16HBE); HUVEC and HEK293 cells NOD/SCID mice [49, 129]
miR-148a Downregulated BCL2 Apoptosis Colorectal cancer RKO, LOVO, W480 cells   [111]
  1. AML, acute myeloid leukemia; EOC, epithelial ovarian cancer; HUVEC, human umbilical vein endothelial cell; NSCLC, non-small cell lung cancer; NPC, nasopharyngeal carcinoma; OSCC, oral squamous cell carcinoma; RCC, renal cell carcinoma; SACC, salivary adenoid cystic carcinoma