Intricate crosstalk between MYB and noncoding RNAs in cancer

Table 1 The role of miRNAs targeted by MYB in cancer development

MYB-targeted miRNAs	Expression	Targeting	Cellular processes	Tumor types	In vitro model	In vivo model	Refs.
miR-520-h	Upregulated	Smad7, MAGI1	Metastasis	RCC, EOC	RCC cell lines (786-O, A-498, OS-RC-2, ACHN, CAKI-1, SKRC39 and HK-2)	BALB/C nude mice	[48]
miR-130a	Upregulated	NDRG2	Cell proliferation, metastasis	SACC	SACC-83, SACCLM cells	Female BALB/C-nu/nu nude mice	[47]
miR-155	Upregulated	PU.1	Cell proliferation, metastasis, cell cycle	AML		PU.1/p53 double-mutant mice	[51]
miR-17-92	Upregulated	FRZB, p21, E2F1	Senescence	Ph-positive leukemia	BV173, SUP-B15 and K562	NOD/SCID gamma mice	[131]
miR-143	Upregulated	Ras	Cell proliferation, apoptosis, DNA repair, metastasis.	Nasopharyngeal carcinoma	Human NPC cell lines, c666-1, 5-8F, CNE1 and CNE2		[42]
miR-1258	Downregulated	SP-1, GRB2	Metastasis, cell cycle, senescence	OSCC, NSCLC	OSCC cell lines (SCC-9, SCC-15); Human NSCLC cell lines (A549, SPCA1, H1299, H358, PC9, 95D,16HBE); HUVEC and HEK293 cells	NOD/SCID mice	[49, 129]
miR-148a	Downregulated	BCL2	Apoptosis	Colorectal cancer	RKO, LOVO, W480 cells		[111]

AML, acute myeloid leukemia; EOC, epithelial ovarian cancer; HUVEC, human umbilical vein endothelial cell; NSCLC, non-small cell lung cancer; NPC, nasopharyngeal carcinoma; OSCC, oral squamous cell carcinoma; RCC, renal cell carcinoma; SACC, salivary adenoid cystic carcinoma

ISSN: 1475-2867