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Table 2 The role of miRNAs targeting MYB in a variety of cancers

From: Intricate crosstalk between MYB and noncoding RNAs in cancer

Targeting MYB

Cellular processes

Tumor types

In vitro model

In vivo model

Refs.

miR-200

Cell proliferation, resistance

Breast cancer

MCF-7, T47D cells

 

[58]

miR-143-3p

Cell proliferation, apoptosis

Breast cancer

Normal breast cell line MCF-10A, breast cancer cell line MDA-MB-435

 

[60]

miR-195

Cell proliferation, apoptosis, metastasis

NSCLC

A549, H129

Female athymic nude mice

[100]

miR-424

Cell proliferation angiogenesis, metastasis

Ovarian cancer

The normal human ovarian epithelial cell line HOSEpiC, human ovarian cancer cell lines (SKOV-3, HO8910, A2780), HUVECs

Immunodeficient female nude mice

[121]

miR-548c-3p

Cell proliferation, metastasis

Glioma

The human glioma T98G, U87, U251, HEK-293 cells (CRL-1573)

 

[68]

hsa-miR-495

Cell proliferation, metastasis

Glioma

Human glioma cell lines (A172, U87, U251, U373)

 

[69]

miR-150

Cell proliferation, apoptosis, cell cycle

Colorectal cancer, liver cancer, CML

K562, Meg-01, KCL-22, HL-60, KG-1; colorectal cancer cell line

Nude mice

[72, 73, 113]

miR-130a

Angiogenesis

GC

The human gastric cell line SGC7901, the human gastric mucosal epithelial cell line GES-1

Female nude mice (BALB/C-nu, 6–8 weeks)

[118]

miR-155

Angiogenesis

GC

Human SGC-7901 cells, HEK293T cells, HUVEC cell

Male nude mice (BALB/C-nu)

[120]

miR-29

Cell cycle

Breast cancer

T-47D, MDA-MB-453, MCF-7, MCF-10A cells

 

[61]

miR-193b-3p

Cell proliferation

T-ALL

T-ALL cell lines

T-ALL patient samples

[67]

miR-103a

Cell proliferation, metastasis

GC

MKN-45, HGC-27, MGC-803, SGC-7901, GES

 

[30]

  1. CML, chronic myeloid leukemia; GC, gastric cancer; HEK, human embryonic kidney; HUVECs, human umbilical vein endothelial cells; MDA, malonaldehyde; NSCLC, non-small cell lung cancer; T-ALL, T cell acute lymphoblastic leukemia; PHFG, primary human fetal glial