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Table 3 The role and mechanism of MYB-related lncRNAs in cancer

From: Intricate crosstalk between MYB and noncoding RNAs in cancer

LncRNA

Molecular functions

Effects on MYB expression

Mechanism

Cellular processes

In vitro model

In vivo Model

Refs.

DRHC

Regulated transcription

Downregulated

Regulates MEK/ERK signaling

Cell proliferation, metastasis

Hh-7 and SK-Hep-1

Male BALB/C nude mice

[83]

MALAT1

Regulated transcription

Upregulated

Aggravating tumorigenesis by abnormally alternate ve splicing

Cell Cycle, cell proliferation

ELA, U2OS, HepG2, WT-MEFs WI38, WI-38-VA13, IMR-90, RKO, HCT116-WT, p532/2 cell and NIH-3T3 cell

 

[76]

AK023391

Regulated transcription

Upregulated

Promotes GC through activation of the PI3K/Akt pathway

Cell cycle, cell proliferation

Human GC cell lines (HGC-27, AGS, SGC-7901, BGC-823, and MGC-803) and gastric epithelial cells-1(GES-1)

Male nude mice

[82]

SNHG10

MiRNA sponge

Upregulated

Sponges miR-150-5p to decrease its suppressive effect on MYB.

Metastasis

SNU-182, Huh-7, Hep3B, SK-Hep1and SNU-38

Male athymic BALB/C nude mice

[86]

LINC01287

MiRNA sponge

Downregulated

Negatively regulates miR-298 expression

Metastasis

HepG-2, HuH7, Bel7402, Hep3B and LO2

Nude mice

[78]

LncRNA NTT

Regulated transcription

Upregulated

Activated Complex Binding

Metastasis

The HCC cell lines (Huh7 and HepG2)

BALB/C athymic nude mice

[85]

ZFAS1

MiRNA sponge

Upregulated

Regulates miR-150/MYB and miR-150/Sp1 pathways

Cell proliferation, apoptosis

Kasumi-1 cells and NB4 cells

Female nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice

[75]

MAFGAS1

MiRNA sponge

Upregulated

Regulates the miR-150-5p/MYB axis

Cell proliferation, metastasis

Breast cancer cells (MDA-MB-231, MCF-7 and MDA-MB-468) and the normal epithelial breast cell line MCF-10A

Female BALB/C nude mice

[81]

UCA1

Regulated transcription

–

SND1 regulates UCA1 expression through MYB and thus affects 5-Fu induced apoptosis of HCC cells

Apoptosis

HepG2 and SMMC-7721

Nude mice

[74]

LOC102724169

Regulated transcription

Downregulated

Inhibited MYB expression in OCCS by attenuating PI3K/AKT signaling.

Apoptosis

The human EOC cell lines SKOV3, HO8910, SKOV3/cisplatin, the normal ovarian cell line IOSE80, and the mouse EOC cell line ID8

Female nude mice and C57BL/6 mice

[84]

  1. AML, acute myeloid leukemia; EOC, epithelial ovarian cancer; GC, gastric cancer; HCC, hepatocellular Carcinoma; MDA, malonaldehyde; OCCS, ovarian cancer with chronic stress; SND1, staphylococcal nuclease and 1-containing Tudor domain