From: Intricate crosstalk between MYB and noncoding RNAs in cancer
LncRNA | Molecular functions | Effects on MYB expression | Mechanism | Cellular processes | In vitro model | In vivo Model | Refs. |
---|---|---|---|---|---|---|---|
DRHC | Regulated transcription | Downregulated | Regulates MEK/ERK signaling | Cell proliferation, metastasis | Hh-7 and SK-Hep-1 | Male BALB/C nude mice | [83] |
MALAT1 | Regulated transcription | Upregulated | Aggravating tumorigenesis by abnormally alternate ve splicing | Cell Cycle, cell proliferation | ELA, U2OS, HepG2, WT-MEFs WI38, WI-38-VA13, IMR-90, RKO, HCT116-WT, p532/2 cell and NIH-3T3 cell | Â | [76] |
AK023391 | Regulated transcription | Upregulated | Promotes GC through activation of the PI3K/Akt pathway | Cell cycle, cell proliferation | Human GC cell lines (HGC-27, AGS, SGC-7901, BGC-823, and MGC-803) and gastric epithelial cells-1(GES-1) | Male nude mice | [82] |
SNHG10 | MiRNA sponge | Upregulated | Sponges miR-150-5p to decrease its suppressive effect on MYB. | Metastasis | SNU-182, Huh-7, Hep3B, SK-Hep1and SNU-38 | Male athymic BALB/C nude mice | [86] |
LINC01287 | MiRNA sponge | Downregulated | Negatively regulates miR-298 expression | Metastasis | HepG-2, HuH7, Bel7402, Hep3B and LO2 | Nude mice | [78] |
LncRNA NTT | Regulated transcription | Upregulated | Activated Complex Binding | Metastasis | The HCC cell lines (Huh7 and HepG2) | BALB/C athymic nude mice | [85] |
ZFAS1 | MiRNA sponge | Upregulated | Regulates miR-150/MYB and miR-150/Sp1 pathways | Cell proliferation, apoptosis | Kasumi-1 cells and NB4 cells | Female nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice | [75] |
MAFGAS1 | MiRNA sponge | Upregulated | Regulates the miR-150-5p/MYB axis | Cell proliferation, metastasis | Breast cancer cells (MDA-MB-231, MCF-7 and MDA-MB-468) and the normal epithelial breast cell line MCF-10A | Female BALB/C nude mice | [81] |
UCA1 | Regulated transcription | – | SND1 regulates UCA1 expression through MYB and thus affects 5-Fu induced apoptosis of HCC cells | Apoptosis | HepG2 and SMMC-7721 | Nude mice | [74] |
LOC102724169 | Regulated transcription | Downregulated | Inhibited MYB expression in OCCS by attenuating PI3K/AKT signaling. | Apoptosis | The human EOC cell lines SKOV3, HO8910, SKOV3/cisplatin, the normal ovarian cell line IOSE80, and the mouse EOC cell line ID8 | Female nude mice and C57BL/6 mice | [84] |