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Table 3 The role and mechanism of MYB-related lncRNAs in cancer

From: Intricate crosstalk between MYB and noncoding RNAs in cancer

LncRNA Molecular functions Effects on MYB expression Mechanism Cellular processes In vitro model In vivo Model Refs.
DRHC Regulated transcription Downregulated Regulates MEK/ERK signaling Cell proliferation, metastasis Hh-7 and SK-Hep-1 Male BALB/C nude mice [83]
MALAT1 Regulated transcription Upregulated Aggravating tumorigenesis by abnormally alternate ve splicing Cell Cycle, cell proliferation ELA, U2OS, HepG2, WT-MEFs WI38, WI-38-VA13, IMR-90, RKO, HCT116-WT, p532/2 cell and NIH-3T3 cell   [76]
AK023391 Regulated transcription Upregulated Promotes GC through activation of the PI3K/Akt pathway Cell cycle, cell proliferation Human GC cell lines (HGC-27, AGS, SGC-7901, BGC-823, and MGC-803) and gastric epithelial cells-1(GES-1) Male nude mice [82]
SNHG10 MiRNA sponge Upregulated Sponges miR-150-5p to decrease its suppressive effect on MYB. Metastasis SNU-182, Huh-7, Hep3B, SK-Hep1and SNU-38 Male athymic BALB/C nude mice [86]
LINC01287 MiRNA sponge Downregulated Negatively regulates miR-298 expression Metastasis HepG-2, HuH7, Bel7402, Hep3B and LO2 Nude mice [78]
LncRNA NTT Regulated transcription Upregulated Activated Complex Binding Metastasis The HCC cell lines (Huh7 and HepG2) BALB/C athymic nude mice [85]
ZFAS1 MiRNA sponge Upregulated Regulates miR-150/MYB and miR-150/Sp1 pathways Cell proliferation, apoptosis Kasumi-1 cells and NB4 cells Female nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice [75]
MAFGAS1 MiRNA sponge Upregulated Regulates the miR-150-5p/MYB axis Cell proliferation, metastasis Breast cancer cells (MDA-MB-231, MCF-7 and MDA-MB-468) and the normal epithelial breast cell line MCF-10A Female BALB/C nude mice [81]
UCA1 Regulated transcription SND1 regulates UCA1 expression through MYB and thus affects 5-Fu induced apoptosis of HCC cells Apoptosis HepG2 and SMMC-7721 Nude mice [74]
LOC102724169 Regulated transcription Downregulated Inhibited MYB expression in OCCS by attenuating PI3K/AKT signaling. Apoptosis The human EOC cell lines SKOV3, HO8910, SKOV3/cisplatin, the normal ovarian cell line IOSE80, and the mouse EOC cell line ID8 Female nude mice and C57BL/6 mice [84]
  1. AML, acute myeloid leukemia; EOC, epithelial ovarian cancer; GC, gastric cancer; HCC, hepatocellular Carcinoma; MDA, malonaldehyde; OCCS, ovarian cancer with chronic stress; SND1, staphylococcal nuclease and 1-containing Tudor domain