Fig. 5
From: Induction and application of ferroptosis in cancer therapy
Dual role of ferroptosis in tumor immunity. a CD8+ T cell-mediated IFNG release inhibits SLC7A11 expression in cancer cells through activation of the STAT1 pathway, thereby inducing tumor cell ferroptosis. b Ferroptotic cancer cell-mediated KRASG12D release increases M2 macrophage polarization through activation of the STAT3 pathway, thereby limiting antitumor immunity