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Fig. 6 | Cancer Cell International

Fig. 6

From: Salvianolic acid B targets mortalin and inhibits the migration and invasion of hepatocellular carcinoma via the RECK/STAT3 pathway

Fig. 6

The signaling pathway was elucidated in hepatocellular carcinoma cells after Sal B treatment. Sal B can specifically bind to mortalin, and increased the degradation of mortalin proteasomes through ubiquitination. The down-regulation of mortalin can lead to the up-regulation of RECK protein. Then its downstream p-STAT3 and Ac-STAT3 were inhibited to enter the nucleus, resulting in a decrease of the invasive and migratory abilities of hepatocellular carcinoma cells

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Cancer Cell International

ISSN: 1475-2867

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