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Fig. 2 | Cancer Cell International

Fig. 2

From: Hypoxia-mediated YTHDF2 overexpression promotes lung squamous cell carcinoma progression by activation of the mTOR/AKT axis

Fig. 2

YTHDF2 overexpression upregulates the protein levels of P-AKT and P-mTOR and induces EMT in LUSC cells. A The western blot detected the expression of mTOR/AKT-related proteins in NCI-H226 and SK-MES-1 cells. B The western blot detected the expression of EMT-related proteins in NCI-H226 and SK-MES-1 cells. C Using the Pearson correlation statistics, we examine the pairwise gene correlation analysis between YTHDF2 and mTOR in LUSC through GEPIA’ TCGA and GTEx expression data. D and E and F YTHDF2 overexpression resulted in significant promotion of cellular proliferation, invasion and migration in NCI-H226 and SK-MES-1 cells, while AKT Kinase inhibitor eliminated the promotion of YTHDF2 overexpression. Data are represented by the mean ± SD of three independent experiments. *P < 0.05 vs. the vector group

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