Table 1 The functions of m6A methyltransferases in OC
From: Emerging role of m6A methylation modification in ovarian cancer
Writer | Expression | Function | Mechanism | Model | Ref. |
|---|---|---|---|---|---|
METTL3 | Up | Promotion | METTL3 methylates pri-miR-126-5p to promote miR-126-5p maturation, leading to the activation of PTEN-mediated PI3K/Akt/mTOR pathway | In vitro; in vivo | [36] |
METTL3 | Up | Promotion | METTL3 increases m6A levels of lncRNA RHPN1-AS1 and contributes to its stability | In vitro | [35] |
METTL3 | Up | Promotion | METTL3 promotes the translation of AXL catalytic-independently | In vitro; in vivo | [37] |
METTL3 | Up | Promotion | Independently of METTl14 and WTAP, METTL3 enhances m6A modification in the mRNA of oncogenes in OC, including AXL, CSF-1, EIF3C and FZD10 | In vitro | [76] |
METTL3 | Up | Promotion | METTL3 knockdown downregulates p-AKT and the downstream effector Cyclin D1 | In vitro | [83] |