Table 3 The functions of m6A RNA binding proteins in OC
From: Emerging role of m6A methylation modification in ovarian cancer
Reader | Expression | Function | Mechanism | Model | Ref. |
|---|---|---|---|---|---|
IGF2BP1 | Unknown | Promotion | In a 3′UTR- and m6A-dependent manner, IGF2BP1 promotes SRF expression to augment SRF-dependent transcription | In vitro | [81] |
YTHDF1 | Unknown | Promotion | YTHDF1 interacts with m6A-modified TRIM29 to promote TRIM29 expression, contributing to CSC features in cisplatin-resistant OC cells | In vitro | [82] |
YTHDF1 | Up | Promotion | In an m6A-dependent manner, YTHDF1 binds to m6A-modified EIF3C mRNA and augments EIF3C translation | In vitro; in vivo | [40] |
YTHDF2 | Up | Promotion | YTHDF2, degraded by FBW7, can recognize m6A-modifed BMF mRNA and accelerate decay of the latter | In vitro; in vivo | [80] |
YTHDF2 | Up | Promotion | YTHDF2, repressed by miR-145, promotes OC progression by decreasing global mRNA m6A levels | In vitro | [112] |