Fig. 6
From: MiR-155-5p suppresses SOX1 to promote proliferation of cholangiocarcinoma via RAF/MEK/ERK pathway
A Schematic illustration of the mechanism by which Mir-155-5p promotes progression of CCA. Mir-155-5p represses SOX1 expression by binding to the 3′UTR region of SOX1, which activates the Raf/MEK/ERK pathway, thus promoting CCA progression. However, low expression level of miR-155-5p would not lead to inhibition of SOX1; in this setting, SOX1 would suppress the Raf/MEK/ERK pathway and inhibit CCA progression