Fig. 4

Exosomal miR-663b promotes angiogenesis in-vitro. A A wound healing assay was performed to detect the migratory ability of HUVECs after treatment with CaSki exosomes, miR-663b-up exosomes, miR-663b-inhibitor exosomes and NC exosomes (magnification ×100). B Transwell assays were performed to detect the effect of HUVECs after treatment with CaSki exosomes, miR-663b-up exosomes, miR-663b-inhibitor exosomes and NC exosomes (magnification ×100). C An in-vitro Matrigel tube formation assay was performed to evaluate the angiogenic ability of HUVECs after treatment with CaSki exosomes, miR-663b-up exosomes, miR-663b-inhibitor exosomes and NC exosomes (magnification ×100). The number of branches and the tube length per field were analyzed. **P < 0.01 and ***P < 0.001. VCL, vinculin