Fig. 5

M2 macrophage secretion of CXCL13 promotes EMT in ccRCC cells via the Akt signaling pathway. A In the presence or absence of Akt inhibitors, MTS detects the effect of M2 macrophages on the proliferation of ACHN and Caki-1. B In the presence or absence of Akt inhibitors, the scratch healing test detects the effect of M2 macrophages on the migration of ACHN and Caki-1. C In the presence or absence of Akt inhibitors, the Transwell chamber test detects the effect of M2 macrophages on the migration and invasion of ACHN and Caki-1. D In the presence or absence of Akt inhibitors, western blotting revealed the effects of M2 macrophages and CXCL13 on ACHN and Caki-1EMT (*P < 0.05)