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Table 3 Meta-analysis on the diagnostic accuracy of LB for detecting EGFR mutations

From: The value of cell-free circulating tumour DNA profiling in advanced non-small cell lung cancer (NSCLC) management

Reference

Study type/ Sample size

Sensitivity/PPA

Specificity/NPA

Concordance/ OPA between tissue and liquid biopsy

Quian et al. [48]

27 studies

N = 3938

60%

94%

n.r

Luo et al. [49]

20 studies

N = 2012

67.4%

93.5%

n.r

Qiu M et al. [50]

27 studies

N = 3110

62%

95.9%

n.r

Mao et al. [51]

25 studies

N = 2605

61%

90%

79%

Zhou et al. [52]

32 studies

N = 4527

70%

98%

n.r

Passiglia et al. [53]

21 studies

N = 1639

67%

80%

n.r

  1. PPA Positive percent agreement, NPA Negative percent agreement, OPA overall percent agreement, n.r. not reported