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Table 3 Meta-analysis on the diagnostic accuracy of LB for detecting EGFR mutations

From: The value of cell-free circulating tumour DNA profiling in advanced non-small cell lung cancer (NSCLC) management

Reference Study type/ Sample size Sensitivity/PPA Specificity/NPA Concordance/ OPA between tissue and liquid biopsy
Quian et al. [48] 27 studies
N = 3938
60% 94% n.r
Luo et al. [49] 20 studies
N = 2012
67.4% 93.5% n.r
Qiu M et al. [50] 27 studies
N = 3110
62% 95.9% n.r
Mao et al. [51] 25 studies
N = 2605
61% 90% 79%
Zhou et al. [52] 32 studies
N = 4527
70% 98% n.r
Passiglia et al. [53] 21 studies
N = 1639
67% 80% n.r
  1. PPA Positive percent agreement, NPA Negative percent agreement, OPA overall percent agreement, n.r. not reported