Fig. 2
From: Extracellular HMGB1 interacts with RAGE and promotes chemoresistance in acute leukemia cells
Extracellular HMGB1 induced autophagy and diminished apoptosis in acute leukemia cells. A Extracellular HMGB1 protected leukemia cells from the damage of ADM by promoting autophagy and diminishing apoptosis, rHMGB1 (0, 25, 50, 100 ng/mL) was added into leukemia cells before the appliance of ADM (0.4 μM). B The diagrams below were the quantitative data of LC3II/I and P62 as well as cleaved caspase 3 in Jurkat and HL-60 cells. GAPDH was used as loading control. Data are the mean ± standard deviation of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001 compared with the untreated group