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Fig. 3 | Cancer Cell International

Fig. 3

From: A reciprocal feedback of miR-548ac/YB-1/Snail induces EndMT of HUVECs during acidity microenvironment

Fig. 3

Downregulation of miRNA-548ac under acidity is critical for EndMT in HUVECs. a The miRNA array data screened the dysregulated miRNAs varied more than 1.5-folds in the HUVECs treated with acidic medium (pH 6.8). b The relative expression of miR-548ac in acidic medium (pH 7.0, pH 6.8) compared to normal (pH 7.4). c The expression of vascular endothelial markers including VE-cadherin, CD31, α-SMA, and Vimentin at mRNA and protein levels in HUVECs in normal, acidic medium or acidic medium with miR-548ac mimics. d The morphology, wound-healing, and transwell migration assay of HUVECs when cells were cultured in normal, acidic medium or acidic medium with miR-548ac mimics. Histograms are the statistical result of the corresponding wound-healing and transwell migration assay

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