Fig. 2
Screening for the target of eIF4A1 in PDAC. a c-MYC expression was significantly downregulated (log2FC = − 1.05, FDR = 0.00192) in the rocaglate CR-31-B-treated group compared with the control group, ranking in the top 0.6% of all the regulated genes. b The expression of eIF4A1 and c-MYC in tumor tissues from the same PDAC patients were analyzed by IHC staining and the results showed that c-MYC is positively correlated with eIF4A1 (n = 44, r = 0.5041, P = 0.0005, Spearman correlation). c The DEPs were enriched in multiple metastasis-associated functions. d GSEA was performed with ribosomal sequencing results. Gene enrichment plots showed that the enrichment of EMT-related gene sets was reduced substantially after eIF4A-intervention