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Fig. 3 | Cancer Cell International

Fig. 3

From: Targeted intervention of eIF4A1 inhibits EMT and metastasis of pancreatic cancer cells via c-MYC/miR-9 signaling

Fig. 3

eIF4A1 targeted c-MYC to promote EMT in pancreatic cells. a Western blot results show that eIF4A1 was highly expressed in the aggressive AsPC-1 cells and minimally expressed in the indolent Capan-2 cells. b, c Downregulation of eIF4A1 or c-MYC increased the expression of E-cadherin but decreased the expression of snail and miR-9. Downregulation of eIF4A1 decreased c-MYC expression, but the changes in c-MYC expression did not influence the expression of eIF4A1. d, e Upregulation of eIF4A1 or c-MYC decreased the expression of E-cadherin but increased the expression of snail and miR-9. Upregulation of eIF4A1 increased c-MYC expression, but the changes in c-MYC expression did not influence the expression of eIF4A1. f Knockdown of eIF4A1 or c-MYC impaired the migratory and invasive capabilities of AsPC-1 cells. g Overexpression of eIF4A1 or c-MYC enhanced the migratory and invasive capabilities of Capan-2 cells. *P < 0.05, **P < 0.01, ***P < 0.001

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