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Table 2 Subgroup analysis on PTCL and NLR

From: Prognostic significance of the neutrophil-to-lymphocyte ratio in peripheral T-cell lymphoma: a meta-analysis

Outcome

Variables

No. of studies

No. of patients

I2

P-value for heterogeneity

P-value for effects model

HR (95% CI)

P-value for meta-regression

OS

ALL

8

921

40.8%

0.107

 < 0.002

2.20 (1.71, 2.83)

 

Region

  Asian

6

790

16%

0.311

 < 0.002

1.97 (1.51, 2.58)

0.054

  Non-Asian

2

131

0

0.732

 < 0.002

5.27 (2.47, 11.25)

 

Cut-off value

  < 3.9

4

560

0

0.586

 < 0.002

1.97 (1.46, 2.66)

0.231

  ≥ 3.9

4

361

62.7%

0.045

0.002

3.64 (1.60, 8.26)

 

Sample size

  < 60

2

87

0

0.988

 < 0.002

6.24 (2.61, 14.93)

0.05

  ≥ 60

6

834

14.20%

0.323

 < 0.002

2.00 (1.53, 2.60)

 

Median age

  < 60

5

757

27.0%

0.241

 < 0.002

2.05 (1.55, 2.70)

0.366

  ≥ 60

2

87

0.0%

0.988

 < 0.002

6.24 (2.61, 14.93)

 

Disease type

 AITL

1

39

0.005

6.29 (1.76, 22.43)

 

 ENKTL

3

553

0

0.39

 < 0.002

2.02 (1.45, 2.81)

0.232

 PTCL

4

329

57.5%

0.07

0.006

2.60 (1.32, 5.13)

0.313

PFS

ALL

3

490

82.9%

0.003

0.742

1.12 (0.57, 2.20)

 
  1. ENKTL extra-nodal natural killer (NK)/T cell lymphoma, nasal type, HR hazard ratio, PTCL peripheral T-cell lymphoma, OS overall survival, PFS progression-free survival, AITL angioimmunoblastic T-cell lymphoma