Outcome | Variables | No. of studies | No. of patients | I2 | P-value for heterogeneity | P-value for effects model | HR (95% CI) | P-value for meta-regression |
---|---|---|---|---|---|---|---|---|
OS | ALL | 8 | 921 | 40.8% | 0.107 | < 0.002 | 2.20 (1.71, 2.83) | |
Region | ||||||||
Asian | 6 | 790 | 16% | 0.311 | < 0.002 | 1.97 (1.51, 2.58) | 0.054 | |
Non-Asian | 2 | 131 | 0 | 0.732 | < 0.002 | 5.27 (2.47, 11.25) | ||
Cut-off value | ||||||||
< 3.9 | 4 | 560 | 0 | 0.586 | < 0.002 | 1.97 (1.46, 2.66) | 0.231 | |
≥ 3.9 | 4 | 361 | 62.7% | 0.045 | 0.002 | 3.64 (1.60, 8.26) | ||
Sample size | ||||||||
< 60 | 2 | 87 | 0 | 0.988 | < 0.002 | 6.24 (2.61, 14.93) | 0.05 | |
≥ 60 | 6 | 834 | 14.20% | 0.323 | < 0.002 | 2.00 (1.53, 2.60) | ||
Median age | ||||||||
< 60 | 5 | 757 | 27.0% | 0.241 | < 0.002 | 2.05 (1.55, 2.70) | 0.366 | |
≥ 60 | 2 | 87 | 0.0% | 0.988 | < 0.002 | 6.24 (2.61, 14.93) | ||
Disease type | ||||||||
AITL | 1 | 39 | – | – | 0.005 | 6.29 (1.76, 22.43) | ||
ENKTL | 3 | 553 | 0 | 0.39 | < 0.002 | 2.02 (1.45, 2.81) | 0.232 | |
PTCL | 4 | 329 | 57.5% | 0.07 | 0.006 | 2.60 (1.32, 5.13) | 0.313 | |
PFS | ALL | 3 | 490 | 82.9% | 0.003 | 0.742 | 1.12 (0.57, 2.20) |