Fig. 5
From: SYT7 acts as an oncogene and a potential therapeutic target and was regulated by ΔNp63α in HNSCC
Knockdown of SYT7 induced cell apoptosis and influenced cell cycle of HN6 and CAL-27 cells and ΔNP63α-SYT7 double knockdown could partially rescue this phenotype. A Wound-healing analysis of SYT7-knockdown HN6 cells. B Wound-healing analysis of ΔNP63α SYT7 double knockdown HN6 cells. C Wound-healing analysis of SYT7-knockdown CAL-27 cells. D Wound-healing analysis of ΔNP63α SYT7 double knockdown CAL-27 cells. E Apoptosis assay of SYT7-knockdown and shCtrl HN6 cells. F Apoptosis assay of ΔNP63α SYT7 double knockdown and shCtrl HN6 cells. G Apoptosis assay of SYT7-knockdown and shCtrl CAL-27 cells. H Apoptosis assay of ΔNP63α SYT7 double knockdown and shCtrl CAL-27 cells. I Cell cycle detection of SYT7-knockdown and shCtrl HN6 cells. J Cell cycle detection of ΔNP63α SYT7 double knockdown and shCtrl HN6 cells. K Cell cycle detection of SYT7-knockdown and shCtrl CAL-27 cells. L Cell cycle detection of ΔNP63α SYT7 double knockdown and shCtrl CAL-27 cells (n = 3). Bars show the mean ± SD. *Represents p < 0.05, **represents p < 0.01, ***represents p < 0.001, ****represents p < 0.0001. Scale bar = 100 μm