Fig. 6From: Imperatorin induces autophagy and G0/G1 phase arrest via PTEN-PI3K-AKT-mTOR/p21 signaling pathway in human osteosarcoma cells in vitro and in vivoIMP suppressed PTEN-PI3K-AKT-mTOR/p21 signaling pathway. Visualized PI3K-AKT (C) and mTOR (D) KEGG pathway heatmap with relative gene expression level. The expression level of key proteins PTEN, PI3K, p-PI3K, AKT, p-AKT, mTOR, p-mTOR and p21 in PTEN-PI3K-AKT-mTOR/p21 pathway of 143B cells (A) and U2OS cells (B) exposed to various concentration of IMP and the semi-quantitative statistical charts of them(E–I) were determined by Western blot. ns p  ≥ 0.05; *p  < 0.05; **p  < 0.01; ***p  < 0.001, one-way ANOVA; data were mean  ±  SDBack to article page