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Fig. 6 | Cancer Cell International

Fig. 6

From: Imperatorin induces autophagy and G0/G1 phase arrest via PTEN-PI3K-AKT-mTOR/p21 signaling pathway in human osteosarcoma cells in vitro and in vivo

Fig. 6

IMP suppressed PTEN-PI3K-AKT-mTOR/p21 signaling pathway. Visualized PI3K-AKT (C) and mTOR (D) KEGG pathway heatmap with relative gene expression level. The expression level of key proteins PTEN, PI3K, p-PI3K, AKT, p-AKT, mTOR, p-mTOR and p21 in PTEN-PI3K-AKT-mTOR/p21 pathway of 143B cells (A) and U2OS cells (B) exposed to various concentration of IMP and the semi-quantitative statistical charts of them(E–I) were determined by Western blot. ns p  ≥ 0.05; *p  < 0.05; **p  < 0.01; ***p  < 0.001, one-way ANOVA; data were mean  ±  SD

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Cancer Cell International

ISSN: 1475-2867

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