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Fig. 8 | Cancer Cell International

Fig. 8

From: Imperatorin induces autophagy and G0/G1 phase arrest via PTEN-PI3K-AKT-mTOR/p21 signaling pathway in human osteosarcoma cells in vitro and in vivo

Fig. 8

IMP inhibited osteosarcoma growth in vivo. A–C IMP treatment significantly reduced the tumor volume in subcutaneous tumor-transplanted nude mouse model. D IMP treatment decreased the weight of tumor issue in tumor-transplanted nude mouse model. E IMP treatment did not alter the bodyweight of animals, compared with the control group. F H&E staining and IHC staining against PTEN, p-AKT, CDK6 and LC3 images on tumor tissues after the treatment of each group. G H&E staining images of vital organs including heart, liver, spleen, lung and kidney of animals in each group. Scale bars equaled 50 μm in E and equaled 100 μm in F. ns p  ≥  0.05; *p  < 0.05; **p  < 0.01; ***p  < 0.001, one-way ANOVA; data were mean  ±  SD

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Cancer Cell International

ISSN: 1475-2867

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