Fig. 8From: SCUBE3 downregulation modulates hepatocellular carcinoma by inhibiting CCNE1 via TGFβ/PI3K/AKT/GSK3β pathwaySchematic diagram of the validation hypothesis of this study: SCUBE3 activates the PI3K/AKT pathway by binding to the TGFβRII receptor to phosphorylate GSK3β to inhibit its kinase activity, thereby inhibiting the ubiquitination of CCNE1, leading to the accumulation of CCNE1 and ultimately promoting the proliferation of liver cancer cellsBack to article page