Fig. 4
From: miR-378d suppresses malignant phenotype of ESCC cells through AKT signaling
miR-378d inhibition promotes metastasis. a Tumor-bearing mice with liver-transplantation tumors; six BALB/c nude mice were in each group. Red and black arrows represent tumor nodules. b Mouse body weight at days 0 and 44, *; mouse died before day 44. Compared with NC-mice, In-mice lost body weight. P = 0.011. c Survival rate of mice. d Liver with transplantation tumors. e Number of hepatic nodules, ns: no significance. f Abdominal metastatic tumors. g Number of abdominal metastasis tumors. P = 0.026. H Orthotopic liver transplantation tumor model of nude mice used KYSE-150-miR-NC and KYSE-150-miR-378d-in cells, h–j Hematoxylin and eosin staining for liver tumors and abdominal metastatic tumors, Yellow arrows: large nuclei, Red lines: tumor margins. scale bar = 100 μm. k immunohistochemical staining of Ki-67 for abdominal metastatic tumors. scale bar = 100 μm