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Table 6 Summary of functional characterization of HCP5 in various cancers

From: LncRNA HCP5 as a potential therapeutic target and prognostic biomarker for various cancers: a meta‑analysis and bioinformatics analysis

Cancers

Expression

Related genes

Role

References

Thyroid carcinoma

Upregulated

miR-22-3p, miR-186-5p, miR-216a-5p, ST6GAL2

Oncogene

[14]

Anaplastic thyroid cancer

Upregulated

miR-128-3p

Oncogene

[10]

Bladder cancer

Upregulated

miR-29b-3p, HMGB1

Oncogene

[28]

Breast cancer

Upregulated

miR-219a-5p, BIRC3

Oncogene

[29]

TNBC

Upregulated

PTEN

Oncogene

[30]

Cervical cancer

Upregulated

miR-15a, MACC1

Oncogene

[31]

ccRCC

Upregulated

miR-140-5p, IGF1R

Oncogene

[12]

Colon cancer

Upregulated

PI3K/AKT/AP1G1

Oncogene

[32]

Colorectal cancer

Upregulated

miR-299-3p, PFN1/AKT

Oncogene

[33]

Colorectal cancer

Upregulated

miR-139-5p, ZEB1

Oncogene

[13]

CSCC

Upregulated

miR-138-5p, EZH2

Oncogene

[34]

ESCC

Upregulated

miR-139-5p/PDE4A

PI3K/AKT/mTOR

Oncogene

[35]

Gastric cancer

Upregulated

miR-299-3p, SMAD5

Oncogene

[36]

Gastric cancer

Upregulated

miR-186-5p, WNT5A

Oncogene

[9]

Gastric cancer

Upregulated

miR-519d, HMGA1

Oncogene

[37]

Gastric cancer

Upregulated

miR-128, HMGA2

Oncogene

[17]

Glioma

Upregulated

miR-139, RUNX1

Oncogene

[42]

Glioma

Upregulated

miR-128

Oncogene

[43]

Hepatocellular carcinoma

Upregulated

miR-29b-3p, DNMT3A

Oncogene

[11]

Large B-cell lymphoma

Upregulated

miR-27b-3p, MET

Oncogene

[44]

Lung adenocarcinoma

Upregulated

miR-203, SNAI

Oncogene

[45]

NSCLC

Upregulated

miR-320, Survivin

Oncogene

[18]

Multiple myeloma

Upregulated

miR-128-3p, PLAGL2

Oncogene

[46]

Neuroblastoma

Upregulated

miR-186-5p, MAP3K2

Oncogene

[47]

OSCC

Upregulated

miR-140-5p, SOX4

Oncogene

[48]

Osteosarcoma

Upregulated

miR-101, EPHA7

Oncogene

[20]

Ovarian cancer

Upregulated

miR-525-5p, PRC1

Oncogene

[49]

Pancreatic cancer

Upregulated

miR-214-3p, HDGF

Oncogene

[8]

Pancreatic cancer

Upregulated

miR-140-5p, CDK8

Oncogene

[38]

Prostate cancer

Upregulated

miR-4656, CEMIP

Oncogene

[50]

Renal cell carcinoma

Upregulated

miR-214-3p, MAPK1

Oncogene

[19]

Retinoblastoma

Upregulated

miR-3619-5p, HDAC9

Oncogene

[51]

Skin cutaneous melanoma

Downregulated

miR-12, RARRES3

Suppressor

[15]

  1. TNBC triple-negative breast cancer, ccRCC clear cell renal cell carcinoma, CSCC cutaneous squamous cell carcinoma, ESCC esophageal squamous cell carcinoma, NSCLC non-small cell lung cancer cells, OSCC oral squamous cell carcinoma