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Fig. 3 | Cancer Cell International

Fig. 3

From: Epigenetic modification and BRAF gene mutation in thyroid carcinoma

Fig. 3

Different tumour suppressor gene methylation and BRAF gene mutation in thyroid cancer. BRAFV600E is located in the 15th exon of the BRAF gene. Its mutation is the T1799A point mutation in the exon, in BRAFV600E mutation, the cell can not complete the normal apoptosis, may further lead to the occurrence of tumors. In thyroid cancer, the BRAF gene usually mutates to BRAFV600E. The presence of promoter methylation in tumour suppressor genes (RASSF1A, SMOC2, TSHR, TERT, SLC5A8, PLEKHS1, PTEN, DAPK, PDLIM4 and RSK4) leads to decreased tumour suppressor genes expression. When the tumour suppressor genes methylation was present at the same time as BRAFV600E, the prognosis was poor in patients with thyroid cancer

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