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Fig. 6 | Cancer Cell International

Fig. 6

From: Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer

Fig. 6

PAF-AH IB2 Knockdown decreased the growth factor kinase pathway in the ovarian cancer cell. The significantly changed genes in PAF-AH 1B2 KD MCAS cells were enriched in the growth factor kinase signalling pathway in endometrial cancer (A). Color indicates significantly up-regulated signals and down-ward (green) ones indicate down-regulated expression levels of the genes. Luminex immune-assay screen identified activated tyrosine kinases in PAF-AH 1B2 KD cancer cell lines (B). Western blot validated the signaling molecules change pattern in the PAF-AH 1B2 KD cells that involved in the epithermal growth factor kinase related signaling pathway (C). *P < 0.05; **P < 0.01, and ***P < 0.001 represented as compared with control

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