Fig. 4
From: The Hippo signaling pathway in leukemia: function, interaction, and carcinogenesis
New druggable agent effective in targeting YAP. The figure shows the drug agents that can be effective in the Hippo signaling pathway. Some of these drugs inhibit YAP/TAZ nuclear localization or block the transcription of target genes. Some others lead to the degradation of these proteins by increasing LATS activity and phosphorylation of the YAP/TAZ complex. LATS large tumor suppressor kinase; Yap Yes-associated protein