The Hippo signaling pathway in leukemia: function, interaction, and carcinogenesis

Table 2 The contribution of microRNAs demonstrated to be involved in the Hippo pathway in leukemia

MicroRNAs	Expression level	Cancer type	Significant value	Samples	References
miR-9	Downregulated	AML	Activating Hippo/YAP signaling	Cell lines (THP-1, HL-60, TF-1, KG-1)	[108]
miR-9	Downregulated	AML	Restrain the sharp increase boost apoptosis	Cell lines (THP-1, HL-60, TF-1, KG-1)	[108]
miR-550-1	Downregulated	AML	WWTR1 gene was a downstream target of miR-550-1	Cell lines (MV4-11, Kasumi-1 cells)	[92]
miR-550-1	Downregulated	AML	Disrupted the proliferation and tumorigenesis of AML cells	Cell lines (MV4-11, Kasumi-1 cells)	[92]
miR-181a	Downregulated	CML	Decreased activation of YAP		[109]
miR-7977	–	AML	miR-7977 inactivated the Hippo-YAP signaling pathway	Human BM CD34 + cells	[110]
miR-7977	–	AML	miR-7977 significantly reduced the expression of Hippo core kinase, STK4, YAP/TEAD	Human BM CD34 + cells	[110]

ALL acute lymphocytic leukemia; AML acute myeloid leukemia; CML chronic myelogenous leukemia; HL-60 human leukemia cell; miR microRNA; STK4 serine/threonine kinase 4; TEAD transcriptional enhanced associate domain; WWTR1 WW domain containing transcription regulator 1; YAP Yes-associated protein

ISSN: 1475-2867