Table 2 Top 10 gene ontology functional enrichment analysis of differentially expressed genes associated with SKCM
Ontology | ID | Description | p-value | Count |
|---|---|---|---|---|
BP | GO:0008544 | Epidermis development | 4.08E−25 | 75 |
BP | GO:0043588 | Skin development | 2.35E−24 | 70 |
BP | GO:0070268 | Cornification | 7.36E−18 | 31 |
BP | GO:0030216 | Keratinocyte differentiation | 2.48E−17 | 50 |
BP | GO:0009913 | Epidermal cell differentiation | 5.57E−17 | 54 |
BP | GO:0001655 | Urogenital system development | 6.88E−16 | 50 |
BP | GO:0030198 | Extracellular matrix organization | 5.69E−14 | 50 |
BP | GO:0043062 | Extracellular structure organization | 6.33E−14 | 50 |
BP | GO:0048871 | Multicellular organismal homeostasis | 1.63E−13 | 58 |
BP | GO:0072001 | Renal system development | 2.40E−13 | 43 |
CC | GO:0062023 | Collagen-containing extracellular matrix | 9.17E−17 | 57 |
CC | GO:0001533 | Cornified envelope | 2.86E−15 | 22 |
CC | GO:0030057 | Desmosome | 6.66E−14 | 14 |
CC | GO:0005911 | Cell–cell junction | 3.21E−12 | 50 |
CC | GO:0045177 | Apical part of cell | 1.02E−09 | 43 |
CC | GO:0016324 | Apical plasma membrane | 5.41E−09 | 37 |
CC | GO:0016323 | Basolateral plasma membrane | 5.73E−07 | 26 |
CC | GO:0016327 | Apicolateral plasma membrane | 3.34E−06 | 7 |
CC | GO:0009925 | Basal plasma membrane | 5.14E−06 | 9 |
CC | GO:0016328 | Lateral plasma membrane | 1.28E−05 | 11 |
MF | GO:0005200 | Structural constituent of cytoskeleton | 1.11E−08 | 20 |
MF | GO:0004866 | Endopeptidase inhibitor activity | 5.13E−07 | 24 |
MF | GO:0098632 | Cell–cell adhesion mediator activity | 1.00E−06 | 12 |
MF | GO:0030414 | Peptidase inhibitor activity | 1.06E−06 | 24 |
MF | GO:0061135 | Endopeptidase regulator activity | 1.06E−06 | 24 |
MF | GO:0050839 | Cell adhesion molecule binding | 2.42E−06 | 45 |
MF | GO:0061134 | Peptidase regulator activity | 2.86E−06 | 26 |
MF | GO:0098631 | Cell adhesion mediator activity | 6.47E−06 | 12 |
MF | GO:0005506 | Iron ion binding | 8.52E−06 | 20 |
MF | GO:0016825 | Hydrolase activity, acting on acid phosphorus-nitrogen bonds | 1.73E−05 | 22 |