Fig. 4
From: miR-133a targets YES1 to reduce cisplatin resistance in ovarian cancer by regulating cell autophagy
MiR-133a targets YES1 and downregulates its expression. A and B The miR-133a mimic inhibited YES1 expression in SKOV3-DDP and A2780-DDP cells at both the mRNA (A) and protein (B) levels. C and D MiR-133a inhibitor upregulated YES1 expression in SKOV3 and A2780 cells at both the mRNA (C) and protein (D) levels. E The miR-133a mimic reduced the YES1 overexpression function induced by YES1-OE, but the miR-133a inhibitor had no effect on the overexpression of YES1 compared with the miR-133a NC + YES1-OE group. F Cotransfection of the YES1-OE vector together with miR-133a mimic transfection antagonized YES1-OE-induced cisplatin resistance. For comparisons, Student’s t test was performed; *p < 0.05, **p < 0.01