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Fig. 1 | Cancer Cell International

Fig. 1

From: Conjoint analysis of circulating tumor cells and solid tumors for exploring potential prognostic markers and constructing a robust novel predictive signature for breast cancer

Fig. 1

Identify a special cluster with distinct gene expression and outcome in single-CTC cohorts of breast cancer. A Analysis of a breast cancer single-CTC RNA-Seq dataset identifies 3 clusters from unsupervised t-SNE clustering in GSE109761. B The marker genes expressed in 3 clusters of GSE109761. C KEGG pathway analysis of Cluster 1 highly expressed marker genes in GSE109761. D KEGG pathway analysis of marker genes with low Cluster 1 expression in GSE109761. E The heatmap shows the differentially expressed genes between Cluster 1 and other samples of GSE109761. F Analysis of a breast cancer scRNA-Seq dataset identifies 3 clusters from unsupervised t-SNE clustering in GSE144494. G Kaplan–Meier (K-M) curve shows the survival difference of Cluster 1 and others of GSE144494. H Different expression gene orders of GSE109761 were applied in GSE144494 as a validation set

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Cancer Cell International

ISSN: 1475-2867

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