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Fig. 4 | Cancer Cell International

Fig. 4

From: Conjoint analysis of circulating tumor cells and solid tumors for exploring potential prognostic markers and constructing a robust novel predictive signature for breast cancer

Fig. 4

The risk score correlated with aggressive clinicopathology types in breast cancer. The mean value of the risk score in Cluster 1 or others in GSE109761 (A; left picture) and GSE144494 (B; left picture). Receiver operating characteristic curve (ROC) analysis of the risk score for detecting Cluster 1 patients in GSE109761 (A; right picture) and GSE144494 (B; right picture). Kaplan–Meier curves for DFS according to the risk score classification in TCGA (C), METABRIC (D), and GSE25066 (E). The mean value of the risk score in different TNM stages in the TCGA (F), METABRIC (H), and GSE25066 (J) cohorts. Reclassification of survival curves according to the risk score classification within each TNM stage in the TCGA (G), METABRIC (I), and GSE25066 (K) cohorts. Boxplots show the risk score of primary tumors and metastases of patients who later developed metastasis to the lung (L: GSE2603; M: GSE5327), bone (N: GSE2034), or brain (O: GSE2034). The Kaplan–Meier survival plots depict metastasis-free survival for distant metastasis (P: GSE5327), distant relapse (Q: GSE17707), total relapse (L: GSE2034), and lung metastasis (S: GSE2603); (T: GSE5327) based on the premetastatic primary tumor risk score classification

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Cancer Cell International

ISSN: 1475-2867

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