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Table 1 Univariate and Multivariate Cox Analysis of variables with DFS

From: Conjoint analysis of circulating tumor cells and solid tumors for exploring potential prognostic markers and constructing a robust novel predictive signature for breast cancer

Variables

Univariate analysis

Multivariate analysis

HR (95%CI)

p

HR (95%CI)

p

TCGA

 Age (> 50 vs ≤ 50)

1.293 (0.885–1.889)

0.184

  

 T

 

 < 0.0001

 

0.007

  T1

1 (reference)

 

1 (reference)

 

  T2

1.525 (0.967–2.405)

 

1.138 (0.710–1.825)

 

  T3

2.521 (1.436–4.424)

 

1.928 (1.062–3.500)

 

  T4

9.417 (4.725–18.767)

 

3.178 (1.441–7.006)

 

 N

 

 < 0.0001

 

0.003

  N0

1 (reference)

 

1 (reference)

 

  N1

1.416 (0.919–2.184)

 

1.152 (0.738–1.797)

 

  N2

2.821 (1.733–4.594)

 

1.748 (1.024–2.986)

 

  N3

4.246 (2.446–7.370)

 

2.976 (1.611–5.498)

 

 Molecular subtypes

 

0.009

 

0.088

  Luminal A&B

1 (reference)

 

1 (reference)

 

  HER2 positive

2.902 (1.346–6.258)

 

2.041 (0.926–4.498)

 

  Triple negative

1.535 (0.949–2.485)

 

1.469 (0.884–2.442)

 

  Risk score (high vs low)

2.833 (1.994–4.025)

 < 0.0001

2.506 (1.723–3.644)

 < 0.0001

METABRIC

 Age (> 50 vs ≤ 50)

1.403 (1.204–1.635)

 < 0.0001

1.326 (1.134–1.551)

 < 0.0001

 T

 

 < 0.0001

 

 < 0.0001

  T1

1 (reference)

 

1 (reference)

 

  T2

1.559 (1.381–1.759)

 

1.371 (1.211–1.552)

 

  T3

2.316 (1.804–2.974)

 

1.784 (1.381–2.305)

 

 N

 

 < 0.0001

 

 < 0.0001

  N0

1 (reference)

 

1 (reference)

 

  N1

1.321 (1.162–1.501)

 

1.245 (1.093–1.418)

 

  N2

2.162 (1.769–2.641)

 

1.887 (1.540–2.314)

 

  N3

4.144 (3.300–5.203)

 

3.411 (2.699–4.311)

 

 Molecular subtypes

 

0.099

 

0.857

  Luminal A&B

1 (reference)

 

1 (reference)

 

  HER2 positive

1.244 (0.986–1.570)

 

1.011 (0.793–1.288)

 

  Triple negative

0.925 (0.783–1.094)

 

0.955 (0.805–1.132)

 

  Risk score (high vs low)

1.413 (1.255–1.591)

 < 0.0001

1.294 (1.145–1.463)

 < 0.0001

GSE25066

 Age (> 50 vs ≤ 50)

1.072 (0.728–1.579)

0.723

  

 T

 

 < 0.0001

 

0.049

  T1

1 (reference)

 

1 (reference)

 

  T2

1.520 (0.470–4.914)

 

1.472 (0.453–4.776)

 

  T3

2.200 (0.673–7.188)

 

1.788 (0.544–5.877)

 

  T4

4.370 (1.326–14.404)

 

2.885 (0.857–9.714)

 

 N

 

 < 0.0001

 

0.002

  N0

1 (reference)

 

1 (reference)

 

  N1

2.670 (1.504–4.741)

 

2.271 (1.275–4.048)

 

  N2

5.088 (2.650–9.768)

 

3.689 (1.881–7.236)

 

  N3

4.162 (1.944–8.911)

 

2.509 (1.142–5.515)

 

 Molecular subtypes

 

 < 0.0001

 

 < 0.0001

  Luminal A&B

1 (reference)

 

1 (reference)

 

  HER2 positive

3.734 (0.513–27.197)

 

3.854 (0.510–29.123)

 

  Triple negative

3.519 (2.365–5.236)

 

3.157 (2.108–4.729)

 

  Risk score (high vs low)

2.159 (1.452–3.209)

 < 0.0001

1.948 (1.304–2.910)

0.001

  1. The variables with p < 0.1 in univariate Cox Regression Analysis were selected for the further multivariate Cox Regression Analysis
  2. DFS disease free survival, HR hazard ratio, CI confidence interval, vs versus