Variables | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95%CI) | p | HR (95%CI) | p | |
TCGA | ||||
 Age (> 50 vs ≤ 50) | 1.293 (0.885–1.889) | 0.184 |  |  |
 T |  |  < 0.0001 |  | 0.007 |
  T1 | 1 (reference) |  | 1 (reference) |  |
  T2 | 1.525 (0.967–2.405) |  | 1.138 (0.710–1.825) |  |
  T3 | 2.521 (1.436–4.424) |  | 1.928 (1.062–3.500) |  |
  T4 | 9.417 (4.725–18.767) |  | 3.178 (1.441–7.006) |  |
 N |  |  < 0.0001 |  | 0.003 |
  N0 | 1 (reference) |  | 1 (reference) |  |
  N1 | 1.416 (0.919–2.184) |  | 1.152 (0.738–1.797) |  |
  N2 | 2.821 (1.733–4.594) |  | 1.748 (1.024–2.986) |  |
  N3 | 4.246 (2.446–7.370) |  | 2.976 (1.611–5.498) |  |
 Molecular subtypes |  | 0.009 |  | 0.088 |
  Luminal A&B | 1 (reference) |  | 1 (reference) |  |
  HER2 positive | 2.902 (1.346–6.258) |  | 2.041 (0.926–4.498) |  |
  Triple negative | 1.535 (0.949–2.485) |  | 1.469 (0.884–2.442) |  |
  Risk score (high vs low) | 2.833 (1.994–4.025) |  < 0.0001 | 2.506 (1.723–3.644) |  < 0.0001 |
METABRIC | ||||
 Age (> 50 vs ≤ 50) | 1.403 (1.204–1.635) |  < 0.0001 | 1.326 (1.134–1.551) |  < 0.0001 |
 T |  |  < 0.0001 |  |  < 0.0001 |
  T1 | 1 (reference) |  | 1 (reference) |  |
  T2 | 1.559 (1.381–1.759) |  | 1.371 (1.211–1.552) |  |
  T3 | 2.316 (1.804–2.974) |  | 1.784 (1.381–2.305) |  |
 N |  |  < 0.0001 |  |  < 0.0001 |
  N0 | 1 (reference) |  | 1 (reference) |  |
  N1 | 1.321 (1.162–1.501) |  | 1.245 (1.093–1.418) |  |
  N2 | 2.162 (1.769–2.641) |  | 1.887 (1.540–2.314) |  |
  N3 | 4.144 (3.300–5.203) |  | 3.411 (2.699–4.311) |  |
 Molecular subtypes |  | 0.099 |  | 0.857 |
  Luminal A&B | 1 (reference) |  | 1 (reference) |  |
  HER2 positive | 1.244 (0.986–1.570) |  | 1.011 (0.793–1.288) |  |
  Triple negative | 0.925 (0.783–1.094) |  | 0.955 (0.805–1.132) |  |
  Risk score (high vs low) | 1.413 (1.255–1.591) |  < 0.0001 | 1.294 (1.145–1.463) |  < 0.0001 |
GSE25066 | ||||
 Age (> 50 vs ≤ 50) | 1.072 (0.728–1.579) | 0.723 |  |  |
 T |  |  < 0.0001 |  | 0.049 |
  T1 | 1 (reference) |  | 1 (reference) |  |
  T2 | 1.520 (0.470–4.914) |  | 1.472 (0.453–4.776) |  |
  T3 | 2.200 (0.673–7.188) |  | 1.788 (0.544–5.877) |  |
  T4 | 4.370 (1.326–14.404) |  | 2.885 (0.857–9.714) |  |
 N |  |  < 0.0001 |  | 0.002 |
  N0 | 1 (reference) |  | 1 (reference) |  |
  N1 | 2.670 (1.504–4.741) |  | 2.271 (1.275–4.048) |  |
  N2 | 5.088 (2.650–9.768) |  | 3.689 (1.881–7.236) |  |
  N3 | 4.162 (1.944–8.911) |  | 2.509 (1.142–5.515) |  |
 Molecular subtypes |  |  < 0.0001 |  |  < 0.0001 |
  Luminal A&B | 1 (reference) |  | 1 (reference) |  |
  HER2 positive | 3.734 (0.513–27.197) |  | 3.854 (0.510–29.123) |  |
  Triple negative | 3.519 (2.365–5.236) |  | 3.157 (2.108–4.729) |  |
  Risk score (high vs low) | 2.159 (1.452–3.209) |  < 0.0001 | 1.948 (1.304–2.910) | 0.001 |