Fig.7

GS suppresses GC growth by targeting miR-216a-5p/FDFT1 axis in vivo. a Representative bioluminescence images at 30 days after subcutaneous injection of luc-MGC-803 cells with overexpression of vectors or FDFT1 and NC or miR-216a-5p mimics, respectively. Mice were fed by normal diet or FMD. b Luminescence signals in (a) represented by overlaid false-color images with the signal intensity. c Curves of tumor volumes as in (a) at the indicated time. d Lactate production was determined in the tumor tissues from (a). e Representative bioluminescence images at 30 days after tail vein injection of luc-MGC-803 cells with overexpression of vectors or FDFT1 and NC or miR-216a-5p mimics, respectively. Mice were fed by normal diet or fasting diet. f Luminescence signals in (e) represented by overlaid false-color images with the signal intensity. g Schematic illustration of miR-216a-5p/FDFT1 axis regulated by GS in this study. Data are presented as means ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001