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Fig. 5 | Cancer Cell International

Fig. 5

From: FTH promotes the proliferation and renders the HCC cells specifically resist to ferroptosis by maintaining iron homeostasis

Fig. 5

FTH protects the HCC cells from iron stress and oxidative damage. A The GO chord plot showed the top 18 significant FTH1-related genes and the 6 most enriched GO pathways (data from GeneMANIA database). B Control and FTH overexpression HCCLM3 cells were cultured with or without cystine-free medium and subjected to the western blotting assay for the detection of iron metabolism proteins. C Intracellular Fe2+ was examined by the staining of RPA probe and photographed by the confocal microscope (Scale bars 10 μm). D The quantitation of RPA fluorescence intensities was shown. E The staining of mitoSOX and DCF-DA was photographed by the confocal microscope (Scale bars 10 μm). F, G Corresponding quantitative histograms were presented. (Values are represented as mean ± SD. P < 0.05, P < 0.01 versus indicated groups)

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