Fig. 5
From: STK25 enhances hepatocellular carcinoma progression through the STRN/AMPK/ACC1 pathway
Interaction between STK25 and STRN. a Subnetworks of striatum interacting phosphatase and kinase complex (STRIPAK) [17]. b Protein networks related to STK25 from String program. c Pearson correlation between STK25 and STRN from GEPIA. d Determining the interaction between STK25 and STRN by Coimmunoprecipitation. e Representative IHC staining images (200×) of STK25 and STRN expression in liver of control and HCC patients, the thick black arrow indicated STK25. f STRN was overexpressed in STK25 knockdown cells, and proteins related to AMPK/ACC signaling pathway were detected by western blot. g Pearson correlation between STRN and AMPK, ACC1, ACLY. h, i Oil Red O test. The red color is intracellular lipid droplets. CON, control. sh, knockdown. flag, overexpression. *, p < 0.05. **, p < 0.01. ***, p < 0.001. Scale bars, 50 μm